Investigating the Pro-apoptotic, Anti-Cell Proliferation, and Cytotoxic effects of a redox-inactive derivative of Tocotrineol.
DELTA-TOCOTRIENOLS CAN SUPPORT
INHIBITION OF CELL PROLIFERATION
ATTENUATION OF TUMOR INVASION AND METASTASIS
INCREASE OF miR-451 EXPRESSIONS
REPRESSED EXPRESSION OF MMP-9 &Upa PROTEINS
Vitamin E has been one of the most prominent antioxidants of all time. Tocopherols, a group of fours isoforms of Vitamin E, has been consumed to a large scale till date. But, in several latest studies and research, it has been observed that Tocotrienols, which is the other group of the four isoforms of Vitamin E have incredible anticancer, antioxidant, and anti-inflammatory benefits!
Introduction to Mesothelioma and Tocotrienol
Malignant Mesothelioma (MM) is a very aggressive cancer and usually occurs in people who have been exposed to asbestos for a long period of time. It is formed in the lining of the abdomen, lungs, and heart. Although restrictions have been placed on asbestos, yet the cases have been increasing owing to its long latency period. It has been estimated that 3000 people in the United States are diagnosed with Mesothelioma each year and the chances of survival are very low for the next five years from the time of prognosis.
In this study, a new redox-derivative of Tocotrienol, 6-O-carboxypropyl-α-Tocotrienol to investigate its anti-cancer properties on Mesothelioma cells. The redox derivative of Tocotrienol was introduced to investigate its ability induce strong cytotoxicity on MM cells. Hence, in this study, the focus has been laid on the several anticancer effects like induction of apoptosis, anti-cell proliferation, and cytotoxicity of the redox derivative of Tocotrienol.
How does the Redox Derivative Tocotrienol fight Mesothelioma?
In this research, the anti-proliferative effects of Tocotrienol on human malignant mesothelioma cancer cells were discovered. It was observed that Tocotrienols suppress both the activity and expression of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase which results in suppression of cancer promoting functions like angiogenesis and cell proliferation.
MM cells have been observed to have chemo-resistance against cisplatin but when treated with Tocotrienols, the growth of the cancer cells was suppressed! Moreover, the cytotoxic effects of the redox derivative of Tocotrienols on the cancer cells was incredible.
It was also observed in the study that the Tocotrienols suppressed the blood supply to the tumor thus preventing the expansion of the tumor mass by inducing anti-angiogenesis and apoptosis in the cancer cells.
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