To investigate the possibility of MMP-9 inhibition as the mechanism underlying the antimetastatic properties of Delta-Tocotrienol on NSCLC cells.
The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human lung cancer cells, kindly refer to the reference link provided at the bottom of this abstract.




Introduction to Lung Cancer and Delta-Tocotrienols
Lung cancer is the leading cause of cancer-related deaths among both women and men. Lung cancer constitutes 25% of all cancer-related deaths. Every year, more people die of lung cancer than that of breast, prostate, and colon cancers combined! The anti-invasive effects of Delta-Tocotrienol and its underlying cellular mechanism in NSCLC had not been fully explored. In this study, the effects of Delta-Tocotrienol on cell invasion, migration, adhesion, aggregation, and proliferation capabilities were investigated using different cell-based assays.
How does Delta-Tocotrienol fight Lung Cancer?
In the study, it was observed that Delta-Tocotrienols inhibited cell invasion, migration, adhesion, aggregation, and proliferation in a concentration-dependent manner. Matrix metalloproteinase (MMP-9) based cell migration and invasion are critical mechanisms in cancer growth and development. Hence, it was also observed that Delta-Tocotrienols reduced MMP-9 activities. The Western blot and real-time PCR analysis data also demonstrated that Delta-Tocotrienol was able to increase miR-451 expressions and was able to downregulate Notch-1 mediated NF-kB, which resulted in the repression of the expression of MMP-9 and uPA proteins. Hence, it was shown that Delta-Tocotrienols attenuated tumor invasion and metastasis. All the data generated in the study suggested that Delta-Tocotrienols may have a very potent therapeutic benefit against non-small-cells lung cancer (NSCLC) metastasis.
Suggested Usage:
Eannatto DeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 400-900g of dosage of Tocotrienols, have been suggested by researchers for patients suffering from cancer. Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil.
References for the study in detail:
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